Lady Macbeth of the Mtsensk District (Russian: Ledi Makbet Mtsenskogo Uyezda) is an opera in four acts by Dmitri Shostakovich, his Op.29. The libretto was written by Alexander Preis and the composer, and is based on the story Lady Macbeth of Mtsensk District by Nikolai Leskov. The opera is sometimes referred to informally as Lady Macbeth when there is no confusion with Verdi's Macbeth. It was first performed on 24 January 1934 at the Leningrad Maly Operny. Shostakovich dedicated the opera to his first wife, the physicist Nina Varzar.
The work incorporates elements of expressionism and verismo. It tells the story of a lonely woman in 19th century Russia, who falls in love with one of her husband's workers and is driven to murder.